Pharmaceutical Biotechnology Services

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Nishka Labs brings several years of experience of performing all types of analytical solutions. Our technical know-how and extensive experience with analysing and interpretation allow us to develop a range of authenticated results.

Anti Cancer Activity

  • Cytotoxicity assay by MTT/SRB/Trypan blue
  • Clonogenic assay
  • Apoptosis – Nuclear staining with DAPI
  • Alkylating activity assay
  • TUNEL assay
  • Endonuclease assay
  • DNA fragmentation analysis / DNA ladder assay
  • Cancer specific gene expression analysis (P53, BCl2, Capsase 3, VEGF, cyclin D1, cyclin B1, STAT3 etc.)

Anti Diabetes Activity

  • Glucose uptake studies in skeletal muscle cell lines (Non-radio labeled assay).
  • Glucose uptake in isolated rat hemi diaphragm
  • Gene expression studies (PPARγ, GLUT-4 etc)
  • Alpha-Amylase inhibitory activity
  • Alpha-galactosidase inhibitory activity
  • Alpha-glucosidase activity

Hepatoprotective Activity

  • Hepatoprotective study against selected toxicant.
  • Hepatoprotective study in isolated primary rat hepatocytes.
  • Gene expression studies

Anti infective Activity

  • Anti microbial activity by Zone of inhibition.
  • Anti microbial activity by MIC determination
  • Antibiotic sensitivity testing
  • TLC bioautography
  • In vitro anti viral studies


We offer other in vivo services in

  • Hypercholesterolemia
  • Arthritis
  • Osteoporosis
  • Benign prostatic Hyperplasia
  • Spermatogenesis
  • Allergy
  • Antitussive
  • Psoriasis

Other in-vitro Services

  • Anti microbial
  • Anti viral
  • Cytotoxicity
  • Cell proliferation
  • Cancer
  • Diabetes
  • Hepatoprotection
  • Obesity
  • Immunomodulatory
  • Inflammation
  • Skin whitening
  • Skin irritation (Dermal toxicity)
  • Psoriasis
  • Wound healing
  • Genotoxicity
  • Drug permeability
  • Gene expression analysis
  • Enzyme and Immunoassays (ELISA)

Antioxidant Activity

  • DPPH scavenging assay
  • Scavenging of Nitric Oxide radical
  • Lipid peroxidation inhibitory activity
  • Evaluation of Total Antioxidant capacity
  • Ferric ion reducing power assay
  • Scavenging of Hydroxyl Radical by p-NDA Method
  • Scavenging of Hydrogen Peroxide
  • Scavenging of ABTS radical cation Assay
  • Total Phenolic and Flavonoid content estimation

Immunomodulatory & Inflammation Activity

  • Phagocytic assay on cellular lysosomal enzyme activity
  • Proliferation assay
  • NO and TNF inhibitory studies
  • HRBC membrane stabilization
  • Inhibition of protein denaturation
  • Proteinase inhibitory action
  • Analysis of markers like COX-1, COX-2, PGE-2, iNOS, IFN-alpha, IFN-gamma, TNF-alpha, Interleukin (IL)-1, IL-10, IL12, IL-18 etc.

Anti Obesity Activity

  • Anti adepogensis studies in 3T3L-1 pre adepocytes by
    Oil Red-O staining
    Cell triglyceride assay
    Gene expression studies (PPAR-gamma, SREBF etc)


  • Cytotoxicity
  • Genotoxicity
  • AMES test
  • Chromosomal aberration in CHO-K1 cells
  • Micronucleus assay
  • In vitro organ specific toxicity
  • Skin irritation studies (as OECD)
  • In vivo toxicity studies
    – Acute
    – Sub acute
    – Chronic
  • Specific organ toxicity
  • Reproductive toxicity


  • Microbial Analysis (TMC & TFC)
  • Most Probable Number (MPN)
  • Specific pathogen detection
  • Preservative efficacy testing (PET)
  • Sterility testing
  • Bacterial Endotoxin Test (BET)
  • Water analysis


  • Glucose oxidase & Lactoperoxidase determination
  • Analysis of products for Gliadin, Aflatoxins, mycotoxins etc
  • Marker analysis of herbal products
  • Disintegration studies for formulations
  • Dissolution studies for formulations
  • Pyrogen testing
  • In vitro skin irritation studies for cosmetics

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