Pharmacology Services

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Nishka Labs brings several years of experience of performing all types of analytical solutions. Our technical know-how and extensive experience with analysing and interpretation allow us to develop a range of authenticated results.

In vivo Activity

  • DLA/EAC induced ascitic tumor model in mice
  • DLA induced solid tumor model in mice

In Vitro Activity

Anti Diabetes Activity

In vivo Activity

  • Alloxan induced diabetic rat model
  • Streptozotocin induced diabetic rat model

In Vitro Activity

  • Glucose uptake studies in skeletal muscle cell lines (Non-radio labeled assay).
  • Glucose uptake in isolated rat hemi diaphragm
  • Gene expression studies (PPARγ, GLUT-4 etc)
  • Alpha-Amylase inhibitory activity
  • Alpha-galactosidase inhibitory activity
  • Alpha-glucosidase activity

Hepatoprotective Activity

In vivo Activity

  • Hepatoprotective study against selected toxicant in rats

In Vitro Activity

  • Hepatoprotective study against selected toxicant.
  • Hepatoprotective study in isolated primary rat hepatocytes.
  • Gene expression studies

Anti infective Activity

In vivo Activity

  • Different wound healing models in mice/rats

In Vitro Activity

  • Anti microbial activity by Zone of inhibition.
  • Anti microbial activity by MIC determination
  • Antibiotic sensitivity testing
  • TLC bioautography
  • In vitro anti viral studies

Other in vivo services

  • Hypercholesterolemia
  • Arthritis
  • Osteoporosis
  • Benign prostatic Hyperplasia
  • Spermatogenesis
  • Allergy
  • Antitussive
  • Psoriasis

Other Services

  • Antimicrobial
  • Anti viral
  • Cytotoxicity
  • Cell proliferation
  • Cancer
  • Diabetes
  • Hepatoprotection
  • Obesity
  • Immunomodulatory
  • Inflammation
  • Skin whitening
  • Skin irritation (Dermal toxicity)
  • Psoriasis
  • Wound healing
  • Genotoxicity
  • Drug permeability
  • Gene expression analysis
  • Enzyme and Immunoassays (ELISA)

Immunomodulatory & Inflammation Activity

In vivo Activity

  • Carbon clearance assay model
  • Cellular Immune Response Model
  • Humoral Immune Response Model
  • Neutrophil Adhesion Test Model
  • Radiant heat method
  • Tail immersion test
  • Writhing test
  • Paw edema model
  • Oxazolone-induced ear edema in mice

In Vitro Activity

  • Phagocytic assay on cellular lysosomal enzyme activity
  • Proliferation assay
  • NO and TNF inhibitory studies
  • HRBC membrane stabilization
  • Inhibition of protein denaturation
  • Proteinase inhibitory action
  • Analysis of markers like COX-1, COX-2, PGE-2, iNOS, IFN-alpha, IFN-gamma, TNF-alpha, Interleukin (IL)-1, IL-10, IL12, IL-18 etc.

Anti Obesity Activity

In vivo Activity

  • Triton induced hyperlipidemia model in mice/rats
  • Cocktail induced hypercholesterolemia model

In Vitro Activity
Anti adepogensis studies in 3T3L-1 pre adepocytes by

  • Oil Red-O staining
  • Cell triglyceride assay
  • Gene expression studies (PPAR-gamma, SREBF etc)

Toxicology

  • Cytotoxicity
  • Genotoxicity
  • AMES test
  • Chromosomal aberration in CHO-K1 cells
  • Micronucleus assay
  • In vitro organ specific toxicity
  • Skin irritation studies (as OECD)
  • In vivo toxicity studies
    Acute
    Sub acute
    Chronic
  • Specific organ toxicity
  • Reproductive toxicity

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